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KMID : 0882420100780020207
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Korean Journal of Medicine
2010 Volume.78 No. 2 p.207 ~ p.214
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Factors determining renal function in Korean patients with autosomal dominant polycystic kidney disease
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Yang Byeong-Yun
Lee Naria
Son Jung-Min
Kang Jin
Seong Eun-Young
Song Sang-Heon
Lee Dong-Won
Lee Soo-Bong
Kwak Ihm-Soo
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Abstract
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Background/Aims: Previous studies of autosomal dominant polycystic kidney disease (ADPKD) in Koreans have been predominantly cross-sectional and insufficient to elucidate factors determining renal function.
Methods: We retrospectively reviewed the medical records of 60 patients who were diagnosed with ADPKD in our hospital from 1995 to 2005. We surveyed the basal characteristics, symptoms, signs, blood and urine laboratory findings, radiologic extrarenal abnormalities, and kidney length through ultrasonography, and these measures were analyzed to identify their relationship to decreased renal function.
Results: The clinical characteristics, such as symptoms and signs, were similar to those reported previously. Following t-tests and simple regression analyses, the statistically significant variables related to renal function deterioration were as follows: hypertension (with decreased renal function, 2.5 mL/min/1.73 m2/year more rapidly than the no-hypertension group, p=0.006), hypercholesterolemia (p=0.007), hypernatremia (p=0.011), mean kidney length (β=0.378, p=0.029), and albumin (β=-2.067, p=0.003). The multiple regression analysis revealed that the significant factors were hypertension (β=0.261, p=0.016), mean kidney length (β =0.211, p=0.047), and hypernatremia (β=0.244, p=0.024).
Conclusions: The independent risk factors for deteriorating renal function in Korean patients with ADPKD were hypertension, hypernatremia, and mean kidney length.
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KEYWORD
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ADPKD, Kidney failure
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